The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 3, June 24（Fri.）　　Room P (501, 502 and 503)

3P-08　　PDF

Analysis of Amino Acids and Other Compounds in Plasma Using LC/MS with Ion Mobility Spectrometry

(1Toyama Pref. Univ., 2Kanazawa Univ.)
oKaito Yamasaki1, Shigehiro Karashima2, Issey Osaka1

In quantitative analysis of amino acids using LC/MS/MS, multiple ion monitoring (MRM) method has been used for highly sensitive and selective detection. In this method, it is possible to analyze about 30 kinds of compounds in one analysis. For the MRM analysis, it is needed to determine the target analytes before the measurement. Therefore, unknown and unexpected metabolites could not be analyzed by MRM. Since comprehensive analysis is required to elucidate the disease in metabolomics, not only amino acids but other compounds such as lipids should be detected. In this study, we suggest the LC/MS with ion mobility for highly sensitive and selective non-target analysis.