Program

Timetable

Timetable (PDF 100KB)
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Plenary Lectures

[Program]

■Plenary Lecture 1

Prof. Makoto Fujita (The University of Tokyo)
Micro Crystalline Sponge Method (MicroCS Method): X-ray Molecular Structure Analysis with MS-quantity Samples

■Plenary Lecture 2

Prof. Keiichi Nakayama (Kyushu University)
Next-Generation Proteomics Opens New Horizons in Medical Biology: Unraveling a Century-Old Enigma of Cancer Metabolism

■Plenary Lecture 3

Prof. Cheng-Chih Richard Hsu (National Taiwan University)
Ambient Mass Spectrometry and Machine Learning in Disease Diagnosis

Award Lecture

■Day 2 Thursday, June 23 [Program]

Oral Sessions

■Day 1 Wednesday, June 22 [Program]
■Day 2 Thursday, June 23 [Program]
■Day 3 Friday, June 24 [Program]

Session Overview

■Session No.

1A-O1

■Title

Frontiers of Protein and Proteomics Research

■Organizer

Jun Adachi (National Institutes of Biomedical Innovation, Health and Nutrition) / Yusuke Kawashima (Kazusa DNA Research Institute)

■Scope

Mass spectrometry has become an indispensable analytical method for protein and proteomics research. In particular, large-scale omics analyses as well as targeted analyses of individual biomolecules to reveal the structure-function relationship have been explored by the state-of-the art mass spectrometric technologies. In this session, we would like to discuss how mass spectrometry contributes to the front lines of various omics sciences as well as structural biology fields. In addition, we want to also discuss the next-generation mass spectrometry for protein analysis. We will call for papers in a wide range of subjects related to protein and proteomics research in order to share the latest knowledge and discuss future prospects.

■Keywords

Proteomics, Post-translational modification, Protein activity, Structural biology

■Session No.

1B-O1

■Title

Instrumentation Development for the Advancement of Mass Spectrometry -Ionization, Measurement, Analysis-

■Organizer

Yoichi Otsuka (Osaka University) / Lee Chuin Chen (Yamanashi University)

■Keynote

Hiroshi Furutani (Osaka University)

■Scope

Mass spectrometry, which precisely measures the information of gas-phase ions, has been developed along with the creation and advancement of various technologies such as ionization, mass separation, ion detection, and data analysis, and has been applied to a wide range of fields including materials, food, environment, drug discovery, and life science. In recent years, the development of instruments for high-speed measurement of large amounts of data and mass spectrometry imaging, as well as the development of analysis methods for the big data obtained from these instruments, has been vigorously pursued. The purpose of this session is to discuss the current status of instrument development for mass spectrometry and the future prospects. Presentations on hardware such as ion optics, ionization, fragmentation, detectors, etc., and software such as analysis of large amounts of data connected to hardware development are welcome. We would like to provide a platform for researchers from different fields to gather and discuss on these topics.

■Keywords

ion optics, ionization, detectors, imaging, data analysis

■Session No.

1C-O1

■Title

Combined Mass Spectrometry of Materials Using Various Analytical Methods and Instruments

■Organizer

Hideya Kawasaki (Kansai University) / Kyosuke Kaneda (KYOCERA Corporation)

■Invited

Shinya Kitagawa(Nagoya Institute of Technology)

■Scope

There are many materials, including organic materials such as polymers and surfactants and organic-inorganic hybrid materials. In the analysis of such multi-component and composite materials, a combined analysis method of various analytical methods/devices is effective in understanding the structure and properties of the materials. Therefore, the purpose of this symposium is to discuss not only mass spectrometry of substances and materials but also material analysis by combined analysis of mass spectrometry with various analytical methods and instruments. We would like to have a lively discussion on separation methods, imaging methods, data analysis methods, different combined analysis methods (NMR, IR, Raman, XPS and other spectroscopic techniques, SEM, AFM, and other observation methods, etc.) with mass spectrometry for analysis of a wide variety of materials.Since this symposium also invites a wide range of public presentations, we expect active submissions of public presentations.

■Keywords

Materials, combined analysis, data analysis

■Session No.

1D-O1

■Title

Session with Young Researchers: Part 1

■Organizer

Yuta Matusoka (Kyushu University) / Masatomo Takahashi (Kyushu University)

■Scope

This session encourages presentations by young researchers who are enthusiastic about mass spectrometry, regardless of the field. Therefore, if you have any mass spectrometry data (either basic or applied), we welcome your presentation. Presentation by ambitious young researchers who aim to become Principal Investigators (P.I.), as well as graduate students, are also desirable.

■Keywords

Young researchers, Future perspective

■Session No.

2A-O1

■Title

Update on Pharmacokinetic Imaging MS

■Organizer

Yuki Sugiura (Kyoto University) / Mitsutoshi Setou (Hamamatsu University School of Medicine)

■Invited

Mitsutoshi Setou (Hamamatsu University School of Medicine)

■Scope

About 15 years have passed since the development and application of pharmacokinetic imaging using mass spectrometry (MS), and certain results have been obtained in its application to small molecule drugs. The advantage of this technology is that it can recognize molecules by directly detecting their compound ions, and it can distinguish between drug components and drug metabolites for imaging. In addition, by adding internal standards labeled with stable isotopes, quantitative analysis is possible. On the other hand, it is difficult to apply imaging MS as a kinetic evaluation method for "drugs other than small molecule drugs," and imaging MS has not yet been utilized. Currently, the detailed in situ pharmacokinetics of major drug discovery modalities such as antibody drugs, antibody-drug conjugates (ADCs), and nucleic acid drugs are unknown. It would be of great value if we could apply imaging MS to these drugs and establish an independent tissue kinetic imaging method for carrier molecules and drug components. In this session, we would like to introduce the current status of quantitative pharmacokinetic imaging in practical use and the challenge to new modalities, from basic technology development to applied research.

■Keywords

Imaging Mass Spectrometry, Pharmacokinetics, Modern Drug Modalities

■Session No.

2A-O2

■Title

Asia and Oceania International Session - New Wind Blowing in Asia -

■Organizer

Yasushi Ishihama (Kyoto University) / Kanako Sekimoto (Yokohama City University)

■Invited

Pang-Hung Hsu (National Taiwan Ocean University, Taiwan)
Kwang Pyo Kim (Kyung Hee University, Korea)

■Scope

Even in the era of "With Corona", the academic dissemination of mass spectrometry from the Asia-Oceania region has not ceased, and it is expanding more and more. AOMSC, which was launched in Tsukuba in 2010, has been expanding every two year, and will be held in Japan again in 2025. In this session, we would like to share the new wind blowing in Asia with you and freely discuss the latest research results in Asia and Oceania regardless of genre.

■Session No.

2B-O1

■Title

Mass Spectrometry for Biomarker Applications in Drug Development

■Organizer

Tatsuya Ikehara (Shionogi & Co., Ltd) / Fumio Osaki (Astellas Pharma Inc.)

■Scope

With the increasing difficulty of drug development, it is becoming more and more important to utilize biomarkers that reflect disease indicators, drug mechanisms, safety, to improve the efficiency of development and the probability of success. In recent years, the development of technologies such as omics and imaging has led to the application of biomarkers to drug development through various approaches using mass spectrometry. In this symposium, we would like to discuss the role of mass spectrometry in the application of biomarkers to drug development in pharmaceutical companies.

■Keywords

biomarker, drug development, clinical, non-clinical, translational research

■Session No.

2B-O2

■Title

Mass Spectrometry Technique to Skillfully Capture the Composition of Natural Products and Foods and Their Changes

■Organizer

Yoshinori Fujimura (Kyushu University) / Akira Oikawa (Kyoto University)

■Keynote

Takehito Sagawa (S&B Foods Inc.)

■Scope

Many natural compounds have diverse structures and biological activities, such as medical and agrochemical lead compounds, natural toxins derived from fish, shellfish, and mushrooms, pigments, and aroma/flavor components. In addition, structure determination and quantitative analysis of functional components in foods, including natural and agricultural products, are essential for the evaluation of bioactivity, and mass spectrometers have played an important role. In the field of food science, where "food for specified health uses (FOSHU)" and "foods with functional claims (FFC)" have been attracting attention, it is an urgent issue to capture not only raw materials but also detailed component changes during cooking, processing, and eating, which greatly contribute to quality, functionality, and safety. In this session, we would like to have presentations the latest research results of mass spectrometry techniques that can capture unique components and changes in composition that support quality, functionality, and safety of natural and agricultural products and foods in a more qualitatively or quantitatively manner, and to discuss the current status and future prospects of these techniques.

■Keywords

natural product, food, bioactive component, quality evaluation, compositional change

■Session No.

2C-O1

■Title

Frontier in Earth and Space Science Developed by the Advanced Isotopic Analysis

■Organizer

Masaharu Tanimizu (Kwansei Gakuin University) / Teruyuki Maruoka (Tsukuba University)

■Invited

Ryuji Okazaki (Kyusyu University)

■Scope

The detection of small differences (0.01-0.1%) in the isotopic ratios of materials in the solar system/earth can provide information on the origin and age of materials, as well as the physical and chemical processes experienced (evaporation, condensation, diffusion, etc.). In this session, titled "Frontiers of Space, Earth, and Environmental Sciences Opened up by Isotopes," we invite presentations on the latest research results using isotopes as tracers. We would like to deepen our mutual understanding of the origin and evolution of terrestrial planets and the processes currently taking place in the Earth's surface environment.

■Keywords

isotope, mass fractionation, geochemistry, radiogenic decay, elemental cycle

■Session No.

2C-O2

■Title

False Positive in Today's Mass Spectrometry

■Organizer

Atsushi Yamamoto (Tottori University of Environmental Studies) / Yutaka Abe (National Institute of Health Sciences)

■Scope

Today's mass spectrometry offers high quality mass spectra data even from trace amounts of samples. The social impact of the conclusions drawn from this is often significant. Mass Spectra analysis is one of the mainstays of organic chemical structure determination, and it is becoming possible to implement a research strategy called Data-Driven Research, in which the starting point is obtained raw data. The term "Digital Transformation" has become a common phrase in our daily conversations, but if the starting data are improperly handled, they become just rubbish pile. In order not to make mass spectral data rubbish, we have to clarify what we can see in the current mass spectrometry and what is false positive.

■Keywords

Trace analysis, Regulatory science, Non-target analysis, Data analysis.

■Session No.

2D-O1

■Title

Session with Young Researchers: Part 2

■Organizer

Yohei Sakaguchi (Fukuoka University) / Kohta Nakatani (Kyushu University)

■Scope

This session encourages presentations by young researchers who are enthusiastic about mass spectrometry, regardless of the field. Therefore, if you have any mass spectrometry data (either basic or applied), we welcome your presentation. Presentation by ambitious young researchers who aim to become Principal Investigators (P.I.), as well as graduate students, are also desirable.

■Keywords

Young researchers, Future perspective

■Session No.

3A-O1

■Title

The Adventures of Mass Spectrometry for Mental Health Research

■Organizer

Daiki Setoyama (Kyushu University)

■Invited

Koichi Tanaka (Shimadzu Corporation)

■Scope

Mental health disorders have been considered elusive as a research field in which the classification of diseases is less dependent on objective or material indicators, and therefore mechanism of pathological conditions has not yet been characterized. Mass spectrometry-based omics analysis is one of the promising approaches to explore such undeveloped areas. In this session, researchers, who have been tackling a wide range of mental health diseases such as dementia and depression as well as the recently occurring social problem on "hikikomori”, will discuss their clinical or analytical problems and provide future perspectives of this fields.

■Keywords

mental health, dementia, depression, hikikomori, mental stress

■Session No.

3A-O2

■Title

Forefront in Metabolome Research

■Organizer

Yoshihiro Izumi (Kyushu University) / Nobuyuki Okahashi (Osaka University)

■Scope

Metabolome analysis has been developed by the progress and fusion of mass spectrometry technology and peripheral technologies such as chromatography, and is used in various fields. In recent years, detailed protocols for metabolome analysis have been published in Japan. In addition, there are increasing opportunities to discuss specific solutions to metabolomics problems such as “identification (annotation) and quantification of metabolites”. For these reasons, the field of metabolomics is entering a new phase through the development of basic technologies such as various analytical methods, metabolite databases, and data mining tools.
In this session, we want to discuss about forefront in metabolome research (e.g., new metabolomics technology and innovative applied research) for the further advances in metabolomics.

■Keywords

Metabolomics, Lipidomics, New technology, Application

■Session No.

3B-O1

■Title

Contamination - Cause and Approach (Workshop by MSSJ Corporate Program Working Group)

■Organizer

Yoshihiko Takinami (Atonarp, Inc.) / Takeshi Serino (Agilent Technologies)

■Scope

LC/MS and GC/MS are widely recognized as important tools for qualitative and quantitative analyses.
Contamination has been an important topic on these methods from the very begining.
Recent advancements on sensitivity makes it quite easy to detect contamination from the points those were not considered as the sources of contamination.
The focus of this session is to desicuss the potential sources of contamination and how to reduce the interference of contamination.

■Keywords

LC/MS, GC/MS, contamination, quantitative analysis

■Session No.

3B-O2

■Title

Mass Spectrometry of Biopharmaceuticals and Virus Vector for Gene Therapy

■Organizer

Susumu Uchiyama (Osaka University) / Noritaka Hashii (National Institute of Health Sciences)

■Invited

Masashi Hyuga (National Institute of Health Sciences)

■Scope

Mass spectrometry of therapeutic biological macromolecules is indispensable for the drug discovery as well as qulity control of them. Specifically, owing to developments of mass spectrometer, improved sample preparation and data analysis, biological macromolecules with highly complex profiles can be reliably analyzed with highjer sensitivity and resolution. In this session, we introduce recent research examples qnd future perspettive of biopharmaceuticals and virus vector for gene therapy using mass spectrometry.

■Keywords

Biopahrmaceruticals, Virus Vector, Gene Therapy, Post Translational Modification, Chemical Modification

■Session No.

3C-O1

■Title

Data Science in Mass Spectrometry

■Organizer

Eisuke Hayakawa (Okinawa Institute of Science and Technology Graduate University) / Nozomu Sakurai (National Institute of Genetics)

■Scope

Modern high-throughput mass spectrometry instruments generate enormous amounts of data in a variety of field. Further, in addition to conventional targeted analysis, recent wide/non-targeted analysis and omics studies lead to explosion of data size and complexity. Such explosion of data size and complexity can be seen in other areas such as genome, medical, and social network services. Data science is currently gaining more importance and attracting attention to deal with such gigantic and complex data in our society. Although Informatic methods such as database, multivariate analysis and machine learning have been already utilized in mass spectrometry, more advanced technologies in data science will definitely expand the capabilities of mass spectrometry. In this session we will focus on data science and the future prospect of mass spectrometry expanded by data science through the presentations of advanced informatics and the latest data analysis in mass spectrometry.

■Keywords

data science, informatics, database, data analysis, machine learning

■Session No.

3C-O2

■Title

Molecular Science and Mass Spectrometry

■Organizer

Akimasa Fujihara (Osaka Metropolitan University) / Yuji Yamada (Fukuoka University)

■Invited

Keijiro Ohshimo (Tohoku University)

■Scope

Mass spectrometry utilizes physical and chemical processes such as ionization, ion/molecule reaction, atomic and molecular collision, electron transfer, and fragmentation. Mass spectrometry-based techniques such as ion mobility spectrometry and laser spectroscopy of mass-selected ions play important roles in the fields of molecular science. This session will focus on both molecular science using mass spectrometry-based techniques and mass spectrometry using physical and chemical processes.

■Keywords

Ionization, Ion-molecule reaction, Atomic and molecular collision, Fragmentation

■Session No.

3D-O1, 3D-O2

■Title

Free Session

■Organizer

Hideya Kawasaki (Kansai University) / Masahiro Miyashita (Kyoto University)

■Scope

As a new attempt, this session invites presentations for the "Free Session" The purpose of this session is to present and discuss free themes related to mass spectrometry, unlike the organized sessions on specific themes. We will focus on discussions to brush up on the research that has not yet obtained sufficient results and research that you are thinking of starting. For this reason, this session will have 12 minutes for presentations and 7 minutes for questions and answers. We hope that the presentations and discussions in this session will create new research fields related to mass spectrometry in the future.

■Keywords

Free Theme, Budding Researchers, Mass Spectrometry

Poster Presentations

■Day 1 Wednesday, June 22 [Program]
■Day 2 Thursday, June 23 [Program]
■Day 3 Friday, June 24 [Program]
■Late-breaking abstract [PDF]

Panel Discussion

Panel Discussion Overview

■Title

Panel Discussion toward a Future Plan of the Mass Spectrometry Society of Japan (MSSJ)

■Organizer

Working Group for Reformation of MSSJ

■Scope

The Working Group for Reformation of MSSJ, which was newly established in response to the spread of new coronavirus infections in 2020, is considering various aspects of the Society's role in the with corona and after corona era. In particular, we have set "increasing the vitality of 'academia'" as an urgent issue, and published proposals for reform mainly in (1) Annual Conference, (2) Journal, (3) Divisions, and (4) Colloquiums in the JMSSJ journal (JMSSJ, vol. 70, pp. 77-79). In this session, we would like to exchange opinions with you on the “Future of the Mass Spectrometry Society of Japan" based on this proposal.