The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 3, June 24（Fri.）　　Room P (501, 502 and 503)

3P-02　　PDF

Functional in depth proteomics of whisker follicles with loss-of-function mutation of KIT

(1Doshisha Univ., 2Kyoto Pref. Univ. Med., 3Shizuoka Graduate University of Public Health, 4Bruker)
Mayuka Kosugi1, oRio Shimosaka1, Hiroki Kato2, Kazuo Kinoshita3, Takashi Nirasawa4, Kengo Yoshii2, Masaya Ikegawa1

The proto-oncogene c-kit mapped to the white-spotting (W) locus located on chromosome 5 in mice encodes the receptor tyrosine kinase (KIT). The Signaling pathway of KIT and its ligand, stem cell factor (SCF) has pleiotropic effects on melanocytic and hematologic development. Through MALDI-IMS in combination with shotgun proteomics of W/c-kit mutant mice, we have demonstrated KIT restriction on hair follicle proteome.