The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
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Award Lecture

Oral Sessions (Day1, Day2, Day3)

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Day 2, June 23（Thu.）　　Room P (501, 502 and 503)

2P-46（2D-O1-0945）　　PDF

Structural determination of a novel insecticidal peptide in the venom of the North African scorpion Compsobuthus werneri

(1Kyoto Univ., 2Al-Azhar Univ.)
oRyusuke Nakamichi1, Alhussin M.A. Megaly2, Mohammed Abdel-Wahab2, Masahiro Miyashita1, Yoshiaki Nakagawa1, Hisashi Miyagawa1

The main components of scorpion venom are peptides, which are known to exhibit various biological activities, such as insecticidal, antibacterial, and antiviral activities. In this study, we analyzed the components of the venom of the North African scorpion Compsobuthus werneri, which has not been studied before, using LC/MS and isolated an insecticidal peptide (Cw-1). The primary structure of Cw-1 was identified using Edman degradation and de novo sequencing analysis, which showed similarity to chlorotoxin-like peptides.