The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 2, June 23（Thu.）　　Room P (501, 502 and 503)

2P-30　　PDF

High Resolution Imaging Platform Incorporating MALDI and DESI

(1Nihon Waters, 2Waters)
oThanai Paxton1, Mark Towers2, Emmanuelle Claude2, Martin Palmer2, Dale Cooper-Shepherd2, Steven Lai2

One key issue in imaging mass spectrometry (MSI) is analyte identification, particularly with regards to small molecules (metabolites/lipids). This is due to the abundance of molecular species with similar masses within a small mass range and no chromatographic separation. One way to improve compound identification confidence is through increased mass resolution and mass accuracy. To achieve this with a trapping style instrument requires a long scan duration. Here we demonstrate a multi reflecting-Time-of-Flight(ToF) instrument providing a mass resolution of up to 200,000 FWHM and a mass accuracy <500ppb with a scan speed of up to 10 Hz. The instrument supports both matrix assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI) sources, specifically designed for imaging applications.