The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 2, June 23（Thu.）　　Room P (501, 502 and 503)

2P-21　　PDF

Stability Assessment of Metoclopramide in Injectable-Mixed High-Calorie Infusion

(1Kobe Pharm. Univ., 2Himeji Dokkyo Univ., 3Sakura pharmacy)
oAtsuko Takeuchi1, Chisato Tode1, Misako Matsukawa2, Etsuko Kuroda3, Reiko Teraoka2

Mass spectrometry is the effective analysis tool to get information on the structure and the concentration of the pharmaceuticals. It's also useful for the stability assessment of them. In this study, stability assessment of metoclopramide in injectable-mixed high-calorie infusion was performed by LTQ Orbitrap Discovery LC-MS/MS system. The remains rate of metoclopramide in high-calorie infusion including glucose fell remarkably under the acid condition. A new peak was appeared with a remains rate decline of metoclopramide. Analysis by LTQ Orbitrap Discovery LC-MS/MS system revealed that this peak was the condensation product of metoclopramide and glucose.