The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 2, June 23（Thu.）　　Room P (501, 502 and 503)

2P-02　　PDF

Pharmacokinetic analysis by mass spectrometric imaging and highly sensitive quantification of metabolites by micro-LC/MS

(1Hamamatsu Univ. Sch. Med., 2Preppers, 3Shimadzu)
oYutaka Takahashi1,2, Ariful Islam1, Takumi Sakamoto1, Koretsugu Ogata3, Satoshi Kasamatsu3, Tomoaki Kahyo1, Mitsutoshi Setou1,2

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) offers semiquantitative analysis with visualization of drugs and their metabolites. Micro-liquid chromatography-mass spectrometry (LC/MS) offers the detection and quantification of small analytes with higher sensitivity. In this study, we are applying a quadrupole time-of-flight mass spectrometer (QTOF-MS) equipped with an atmospheric pressure MALDI source (iMScope QT, Shimadzu, Japan) to explore the localization of drugs and their metabolites in mice. We are also applying micro-LC/MS by using the QTOF-MS equipped with a micro-ESI source for quantitative analysis of those analytes.