The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 1, June 22（Wed.）　　Room P (501, 502 and 503)

1P-19　　PDF

Development of an on-line desalination tube automatic changer for LC/MS: Second Report

(1Preppers, 2Hamamatsu Univ. Sch. Med., 3AUC, 4MS Solutions)
oYutaka Takahashi1,2,4, Takeru Shinba3, Takahiro Koumi3, Takumi Sakamoto2, Sachiki Shimizu4, Mitsutoshi Setou1,2

LC/MS is widely used for both qualitative and quantitative analysis, especially for biological samples such as proteins and drug metabolites, due to its high qualitative ability and detection sensitivity. Phosphate buffer has long been used as a mobile phase in HPLC because of its high separation ability and detection even at low UV wavelengths. However, it is well known that phosphate buffer cannot be used for LC/MS measurements. We have previously developed a desalination tube that uses an ion exchange mechanism to enable on-line LC/MS measurements even under phosphate buffer conditions. In addition, we have developed an automatic changer of the desalination tubes for continuous analysis.