The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 1, June 22（Wed.）　　Room P (501, 502 and 503)

1P-08　　PDF

Neuropathology of Alzheimer's disease dissecting with MALDI imaging mass spectrometry based proteomics and lipidomics

(1Doshisha Univ., 2Bruker Daltonik, 3TMIG)
oYumiko Toyama1, Soichiro Tokuhira1, Nobuto Kakuda1, Taro Sakamoto2, Takashi Nirasawa2, Maho Morishima3, Shigeo Murayama3, Yuko Saito3, Masaya Ikegawa1

Lipid analysis is of great relevance in neuroscience research as they have significant roles as both signaling molecules and structural interactions with membrane proteins. Here w e have developed an applied method that combines pr oteomics and lipidomics through MALDI imaging mass spectrometry to obtain molecular map of in Alzheimer's disease brain . With current strategy, we will characterize proteomic amyloid plaque pathology associated lipid dysregulations in Alzheimer's disease.