The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Poster Presentations

Day 1, June 22（Wed.）　　Room P (501, 502 and 503)

1P-02　　PDF

Chemical Proteomics Analysis of Targeted Proteins of the Covalent Inhibitors

(1Kyushu Univ., 2Nagoya Univ.)
oAkio Ojida1, Keiko Kuwata2, Naoya Shindo1, Keisuke Tokunaga1, Mami Sato1, Kazuhiro Fuchida1

Irreversible inhibition of disease-associated proteins with reactive small molecule is a powerful approach for achieving increased and sustained pharmacological potency. We have recently reported the selective covalent inhibitors exploiting the new class of reactive warheads such asα-chlorofluoroacetamide (CFA) and BCB-amide (bicyclobutane-amide). In this presentation, we report the result of the chemical proteomics analysis using the covalent ligands with these warheads.