演題概要

ポスター発表

第3日　6月24日（金）　　P会場（501，502，503）

3P-02　　PDF

KIT変異マウスwhisker毛包のfunctional in depth proteomics

(¹同志社大生命医・ ²京府医大・ ³静岡社会健康医学大学院大・ ⁴ブルカージャパン)
小杉茉由佳¹・ ^o下坂梨緒¹・ 加藤大貴²・ 木下和生³・ 韮澤崇⁴・ 吉井健悟²・ 池川雅哉¹

The proto-oncogene c-kit mapped to the white-spotting (W) locus located on chromosome 5 in mice encodes the receptor tyrosine kinase (KIT). The Signaling pathway of KIT and its ligand, stem cell factor (SCF) has pleiotropic effects on melanocytic and hematologic development. Through MALDI-IMS in combination with shotgun proteomics of W/c-kit mutant mice, we have demonstrated KIT restriction on hair follicle proteome.