演題概要

オーラルセッション

第3日　6月24日（金）　15:20～15:40　D会場（413，414）

3D-O2-1520　　PDF

質量分析イメージング用新規転写プレートを用いた乳癌由来物質の検出

(¹九大院医・ ²浜松ホトニクス・ ³九大院農・ ⁴伊万里有田病院・ ⁵光産業創成大学院大)
^o野中謙太朗¹・ 池田貴将²・ 岩崎健¹・ 大嶧正隆³・ 小谷政弘²・ 大村孝幸²・ 園田英人^1,4・ 内藤康秀⁵・ 田中充³・ 松井利郎³・ 沖英次¹

Developing a new system to detect cancer-derived substances directly without any preparation is needed due to differences in human resources in each hospital. Breast cancer samples and 7 other frozen breast cancer tissues (T) and noncancerous tissues (N) were directly blotted to a novel transfer plate (Hamamatsu Photonics K.K.). We found several m/z peaks which showed significantly stronger intensity in T than N by the novel transfer plate aided-negative LDI-MS imaging. Furthermore, these m/z were showed reproducibly in all cancer tissue but limit detection in N. The combination m/z we found by using a novel transfer plate, may be useful for early detection and rapid diagnosis of breast cancer.