日本質量分析学会 第70回質量分析総合討論会会

演題概要

オーラルセッション

第3日 6月24日(金) 16:20~16:40 A会場(メインホール)

宇宙環境における酸化ストレスがもたらす生体内脂質変動解析

(1帝京大薬2東北大メガバンク3東北大院医4JAXA)
o小池海斗1三枝大輔1,2宇留野晃2,3鈴木隆史2,3福内友子1山岡法子1芝大4山本雅之2,3

Space travel induces stresses that provoke health problems, and concomitantly induces the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stresses1). While the variation of lipid species in white adipocytes (eWAT) have been identified2), detailed changes of lipid profiles, such as the level of fatty acid, remain unknown. Therefore, we have analyzed eWAT and liver tissues of flight mice and ground control including wild type and Nrf2 knockout mice by means of the lipidomic profiling using a UHPLC-FTMS. The level of eicosapentaenoic acid (EPA) type of phospholipids were significantly increased after space flight, suggesting that EPA may be the key factor for the novel function involved in antioxidant effects of Nrf2 in the space flight.