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3A-O2-1520 PDF
時系列メタボロミクスを用いたタモキシフェン処理後の乳がん細胞株MCF-7の代謝応答解析
In this study, time-series metabolomics was employed to analyze the metabolic responses in the 4-hydroxy tamoxifen (4-OHT)-treated human breast cancer cell line MCF-7. The results revealed that lipid biosynthesis from citrate was activated by 4-OHT treated apoptotic cells. Inhibition of the metabolic responses inhibited cell apoptosis, indicating that activation of lipogenesis via citrate decrease plays a role in inducing apoptosis.