オーラルセッション
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3A-O1-1040 PDF
精神疾患バイオマーカーとしてのトリプトファン代謝産物の測定
Degradation of Trp via the kynurenine pathway produces several biological active metabolites such as kynurenine, kynurenic acid, 3-hydroxykynurenine, and quinolinic acid. It has been reported that the dysregulation of kynurenine pathway is associated with the pathophysiology of several psychiatric diseases such as depression and schizophrenia. For example, the inflammatory state in patients with depression may cause the acceleration of Trp metabolism, which may lead to the accumulation of downstream neurotoxic metabolites, including 3-hydroxykynurenine and quinolinic acid, in the central nervous system. Additionally, elevated kynurenic acid concentrations have been reported in brain tissues and cerebrospinal fluid from patients with schizophrenia.
We investigated the characteristics of serum Trp metabolite profiles in high-risk subjects of major depressive disorder as defined by depression scores. We observed elevated levels of anthranilic acid in the serum derived from high-risk subjects. Furthermore, in subjects who progressed from a healthy state to a depressive state, changes in ratios of anthranilic acid were significantly greater than those in the control group.
These observations indicate that the quantification of Trp metabolites in serum samples can be used as a biomarker for early diagnosis and prognosis prediction for psychiatric disorders.