演題概要

ポスター発表

第2日　6月23日（木）　　P会場（501，502，503）

2P-30　　PDF

MALDI および DESI 対応の 高分解能イメージングプラットフォーム

(¹日本ウォーターズ・ ²ウォーターズ)
^oパクストンタナイ¹・ Towers, Mark²・ Claude, Emmanuelle²・ Palmer, Martin²・ Cooper-Shepherd, Dale²・ Lai, Steven²

One key issue in imaging mass spectrometry (MSI) is analyte identification, particularly with regards to small molecules (metabolites/lipids). This is due to the abundance of molecular species with similar masses within a small mass range and no chromatographic separation. One way to improve compound identification confidence is through increased mass resolution and mass accuracy. To achieve this with a trapping style instrument requires a long scan duration. Here we demonstrate a multi reflecting-Time-of-Flight(ToF) instrument providing a mass resolution of up to 200,000 FWHM and a mass accuracy <500ppb with a scan speed of up to 10 Hz. The instrument supports both matrix assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI) sources, specifically designed for imaging applications.