演題概要

ポスター発表

第2日　6月23日（木）　　P会場（501，502，503）

2P-24　　PDF

イメージング質量分析法を用いた脳腫瘍移植マウス脳の包括的代謝局在解析

(¹同志社大生命医・ ²京大・ ³島津)
^o小林奈央¹・ 近藤夏子²・ 黒﨑洸輔¹・ 櫻井良憲²・ 鈴木実²・ 山口真一³・ 池川雅哉¹

Here we apply an untargeted mass spectrometry-based metabolomics approach by imaging mass spectrometry in combination with UMAP method. The current protocol enabled to visualize differences in broad array of metabolites across anatomical regions of the mouse brain. This study yields important platform of metabolomics phenotyping of the mouse brain by defining regional homeostasis for the normal mouse brain to give context to the reaction to brain tumor as well as boron neutron capture therapy.