日本質量分析学会 第70回質量分析総合討論会会

演題概要

ポスター発表

第2日 6月23日(木)  P会場(501,502,503)

質量分析イメージングによる薬物動態解析とmicro-LC/MSによる代謝物の高感度定量

(1浜松医大2プレッパーズ3島津)
o高橋豊1,2Islam, Ariful1坂本匠1緒方是嗣3笠松郷志3華表友暁1瀬藤光利1,2

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) offers semiquantitative analysis with visualization of drugs and their metabolites. Micro-liquid chromatography-mass spectrometry (LC/MS) offers the detection and quantification of small analytes with higher sensitivity. In this study, we are applying a quadrupole time-of-flight mass spectrometer (QTOF-MS) equipped with an atmospheric pressure MALDI source (iMScope QT, Shimadzu, Japan) to explore the localization of drugs and their metabolites in mice. We are also applying micro-LC/MS by using the QTOF-MS equipped with a micro-ESI source for quantitative analysis of those analytes.