日本質量分析学会 第70回質量分析総合討論会会

演題概要

ポスター発表

第1日 6月22日(水)  P会場(501,502,503)

LC/MS用オンライン脱塩チューブ自動切換え装置の開発:第二報

(1プレッパーズ2浜松医大3エーユーシー4エムエス・ソリューションズ)
o高橋豊1,2,4榛葉健3小海貴裕3坂本匠2清水幸樹4瀬藤光利1,2

LC/MS is widely used for both qualitative and quantitative analysis, especially for biological samples such as proteins and drug metabolites, due to its high qualitative ability and detection sensitivity. Phosphate buffer has long been used as a mobile phase in HPLC because of its high separation ability and detection even at low UV wavelengths. However, it is well known that phosphate buffer cannot be used for LC/MS measurements. We have previously developed a desalination tube that uses an ion exchange mechanism to enable on-line LC/MS measurements even under phosphate buffer conditions. In addition, we have developed an automatic changer of the desalination tubes for continuous analysis.