日本質量分析学会 第70回質量分析総合討論会会

演題概要

ポスター発表

第1日 6月22日(水)  P会場(501,502,503)

イメージング質量分析法を用いたプロテオミクス・リピドミクスを融合したアルツハイマー病の脳病理解析

(1同志社生命医2Bruker Daltonik3都健康長寿医セ研)
o外山友美子1徳平壮一郎1角田伸人1坂本太郎2韮澤崇2森島真帆3村山繫雄3齊藤祐子3池川雅哉1

Lipid analysis is of great relevance in neuroscience research as they have significant roles as both signaling molecules and structural interactions with membrane proteins. Here w e have developed an applied method that combines pr oteomics and lipidomics through MALDI imaging mass spectrometry to obtain molecular map of in Alzheimer's disease brain . With current strategy, we will characterize proteomic amyloid plaque pathology associated lipid dysregulations in Alzheimer's disease.