演題概要

ポスター発表

第1日　6月22日（水）　　P会場（501，502，503）

1P-02　　PDF

ケミカルプロテオミクスによるコバレントドラッグの標的探索

(¹九大院薬・ ²名大ITbM)
^o王子田彰夫¹・ 桑田啓子²・ 進藤直哉¹・ 徳永啓佑¹・ 佐藤磨美¹・ 渕田大和¹

Irreversible inhibition of disease-associated proteins with reactive small molecule is a powerful approach for achieving increased and sustained pharmacological potency. We have recently reported the selective covalent inhibitors exploiting the new class of reactive warheads such asα-chlorofluoroacetamide (CFA) and BCB-amide (bicyclobutane-amide). In this presentation, we report the result of the chemical proteomics analysis using the covalent ligands with these warheads.