- 第1日 6月22日（水） 17:00～17:15 D会場（413，414）
Using a vertical hair-slice section, we compared the components of normal and damaged hair regions using two ionization methods, matrix-assisted laser desorption/ionization and nanoparticle-assisted laser desorption/ionization (nano-PALDI) mass spectrometry. Nano-PALDI is useful for small-molecule and high spatial resolution (5 μm) analyses due to the lack of noise. Thus, clear images were obtained from thin hair samples. In nano-PALDI mass spectrometry imaging, cystine and 18-methyleicosanoic acid as endogenous hair components localized in the cuticle and cortex and cuticle of normal hair, respectively. In contrast, both components were absent in damaged hair.