ランチョンセミナー
- 第4日 5月18日（金） 12:10～13:10 B会場（星雲1）
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4B-L-1210 PDF
標的定量プロテオミクスを用いた創薬研究支援
One of the most important subjects for successful drug discovery and development is to find a rational strategy bridging the significant gap between non-clinical and clinical research. As proteins regulate the cellular function, it is crucial to know their intrinsic activity, expression amounts and localization in the organ. An in-silico design algorithm for an appropriate peptide in the LC-MS/MS quantification enables us to establish protein quantification method in the absence of the protein to be quantified. In the past 10 years, there have been significant progress in the pharmacoproteomics, i.e., quantitative targeted absolute proteomic (QTAP) based research. QTAP should have many potential applications to solving difficult subjects in the drug discovery and development.