オーラルセッション
- 第2日 5月16日（水） 17:30～17:50 C会場（星雲2）
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2C-O3-M-1730 PDF
質量分析イメージングを用いた骨格筋脂質解析
It is clear that lipids are responsible for insulin resistance in skeletal muscle. However, it is poorly understood what types of lipids are involved. In our study, we verified the characteristic lipid species in skeletal muscle. Especially we focused on the lipid variety between slow and fast fiber, respectively and listed slow and fast fiber specific lipids. Moreover, we visualized lipid dynamics of a chronic exercise training model and a high-fat induced-obesity model by mass spectrometry imaging. Mass spectrometry imaging could visualize lipid distribution with molecular species level. As a result, some polyunsaturated fatty acid-containing phosphatidylcholine and sphingomyelin were characterized as chronic exercise training-induced lipids. Due to their influence on cell permeability and receptor stability at the cell membrane, these molecules may contribute to the mechanisms underlying insulin sensitivity and several metabolic disorders in skeletal muscle.