Abstract

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-49　　PDF

Analysis of in vivo gradients of lithium and its metabolites in mouse using multimodal imaging techniques.

(Doshisha Univ.)
^oKeigo Ohara

This study developed a whole animal sectioning method to determine in vivo gradients of lithium (Li) and other metabolites in mice after intraperitoneal (i.p.) and oral administration of pharmacological doses of Li, which is commonly used as a first-line drug for bipolar disorder. The study found that i.p. and oral
administration of Li resulted in different stoichiometric distributions of Li in the head and intestines of the mice. Additionally, a nonlinear dimensionality-reduction technique was used to analyze the metabolic effects of Li administration on various organs. The study suggests that the developed protocol can be used to examine bidirectional communication channels of drugs, nutrients, and endogenous molecules involving neural, endocrine, and inflammatory mechanisms. This could be useful in studying the brain-gut axis in neurological disorders.