Program

Timetable

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Plenary Lecture

[Program]

Prof. Eiichiro Fukusaki (Osaka University)
Application of Metabolomics to High Resolution Phenotype Analysis

Types of Presentations

1. Basic Session & Young Researchers' Session (AM): The Program Committee will review the submitted abstracts and select oral presentations for each research field.
2. Poster Presentations (AM & PM): Poster presentations will be scheduled for abstracts that have been submitted for poster presentation only, as well as for abstracts other than Basic session & Young researchers' session.
3. Symposium Sessions (PM): Oral presentations are determined in advance by the session organizers.

Symposium Sessions

■Day 1 Monday, May 15 [Program]
■Day 2 Tuesday, May 16 [Program]
■Day 3 Wednesday, May 17 [Program]

Session Overview

■Session No.

1A-S

■Title

Mass Spectrometry of Biopharmaceuticals at Pharmaceutical Companies

■Organizer

Takeshi Ota (SHIONOGI & CO., LTD.) / Taishi Kusama (Astellas Pharma Inc.)

■Scope

In the discovery and development of biopharmaceuticals such as antibody drugs and protein vaccines, mass spectrometric analysis has been becoming essential with the growing popularity of multi-attribute method (MAM) for structural characterization, and structural proteomics by hydrogen/deuterium exchange (HDX) MS and crosslinking MS among pharmaceutical companies.
In this session, we will share and discuss the purpose, the situation and the method of structural characterization using MS. Furthermore, issues on the process of data acquiring and utilization will be presented by speakers, we would like to discuss vigorously what MS should be on each developmental stage of biopharmaceuticals.

■Keywords

biopharmaceuticals, antibody, vaccine, Multi Attribute Method, structual proteomics

■Session No.

1B-S

■Title

Novel Structural Analysis and Data Analysis in Mass Spectrometry of Materials

■Organizer

Issey Osaka (Toyama Prefectural University) / Asuka Masumoto (Mitsubishi Chemical Corporation)

■Invited

Shinya Kitagawa (Nagoya Institute of Technology)

■Scope

The focus of this symposium is the application of mass spectrometry (MS) for industrial materials. In industrial fields, the development of functional materials is progressing.
Mass spectrometry is developing into one of the most significant analytical techniques for characterizing these industrial materials at the molecular level. It is important to analyze degradation and pollution of materials in the increasing use of industrial products. Statistical and mechanical analysis have been used because mass spectrometry provides the enormous amount of information. The purpose of this session is to discuss structural analysis and data analysis for materials by mass spectrometry and combined method of mass spectrometry with various analytical methods. We would like to discuss on pretreatment and separation methods, various ionization methods, imaging methods, ion mobility, data analysis methods, different combined other spectroscopic techniques with mass spectrometry.

■Keywords

pretreatment/separation, ionization, imaging, ion mobility, data analysis

■Session No.

1C-S

■Title

A Long and Winding Road of Mass Spectrometry Databases

■Organizer

Fumio Matsuda (Osaka University) / Takeshi Bamba (Kyushu University)

■Invited

Takashi Ito (Kyushu University)

■Scope

The Mass Spectrometry Society of Japan has been actively collecting and compiling mass spectrometry data into databases. Just as a Shogi player leaves behind a game record for future generations, this is because all analysts can leave behind mass spectra data that will be a clue to decipher the structure and physical properties of a measurement target. On the other hand, the utilization of mass spectrometry data is also expanding in an interdisciplinary manner with the spread of mass spectrometry. This symposium aims to provide an overview of past efforts and a forum for dialogue to promote cross-disciplinary development.

■Keywords

Database, proteomics, small molecules, Data availability, software

■Session No.

2A-S

■Title

Technical Challenges in Metabolomics

■Organizer

Masatomo Takahashi (Kyushu University) / Yuta Matsuoka (Kyoto University)

■Scope

Mass spectrometry based metabolomics has been applied in various fields such as pharmaceutical, medicine, food, agriculture, and the environmental researches. Application-based studies/research using current metabolic technologies have been trends in metabolomics. Recently, the number of researches on the technical challenges in metabolomics has been increased (ex. sample preparation, comprehensive metabolome analysis, metabolite identification and quantification). Technological/methodological advances in metabolomics have played a key role in driving the applications in metabolomics research. In this session, we will introduce some researches focused on the technical challenges in metabolomics, and discuss the current status and future of metabolomics.

■Keywords

technical challenges in metabolomics, current status and future of metabolomics

■Session No.

2B-S

■Title

Determination of Trace Compounds in Environment by Mass Spectrometry

■Organizer

Masaharu Tanimizu (Kwansei Gakuin University) / Teruyuki Maruoka (Tsukuba University)

■Keynote

Hikaru Yabuta (Hiroshima University)

■Scope

Mass spectrometry has been applied to determination of ultra-trace compounds in the environment, and has been used to detect radioactive substances, toxic metallic elements, and organic compounds in water, air, and soil including isotopic analysis. In this session, we would like to provide an opportunity to deepen mutual understanding through presentations on both software and hardware, including the establishment of a method for the highly sensitive determination of compounds in the environment and its application in environmental chemistry.

■Keywords

compounds in environment, sensitive detection, elemental circulation, radioactive isotope, isotope analysis

■Session No.

2C-S

■Title

Mass Spectrometry for Quality Assessment of Agricultural Products and Foods

■Organizer

Akira Oikawa (Kyoto University) / Yoko Iijima (Kogakuin University)

■Invited

Toshiro Matsui (Kyushu University)

■Scope

Components contained in foods and agricultural products, which are the raw materials of foods, are important elements directly related to nutrition, taste, health, and other functional properties. Qualitative or quantitative analysis of these components is an essential tool for measuring the quality value of foods and agricultural products. Mass spectrometers have been powerfully utilized as tools for the discovery, structure determination, and highly sensitive quantitative analysis of these valuable natural components. In addition, mass spectrometry has also been used for metabolomic analysis with the application of bioinformatics in recent years.
In this session, we would like to discuss the current status and future prospects about the analysis of useful components in foods and agricultural products, and their application to quality assessment and evaluation of additional values of them.

■Keywords

agricultural products, foods, quality assessment

■Session No.

3A-S

■Title

New Technologies for Protein Analysis Using Mass Spectrometry and Their Applications

■Organizer

Naoyuki Sugiyama (Kyoto University) / Takeshi Masuda (Kumamoto University)

■Scope

Recent years have seen remarkable progress in protein and proteome analysis using mass spectrometry, and they have become essential tools for understanding biological events. However, there are still many issues to be solved, such as improving the sensitivity and comprehensiveness of measurement and understanding the various functions associated with changes in the forms and localization of proteins. In this session, we will focus on various techniques to accelerate protein analysis research and their applications, and discuss a wide range of topics from sample preparation methods to analytical techniques and data analysis.

■Keywords

protein, proteomics, single cell analysis, proteoform, identification/quantification, data analysis

■Session No.

3B-S

■Title

Latest Research on Per- and Polyfluoroalkyl Substances (PFAS) in Japan - What Have We Found?

■Organizer

Sokichi Takagi (Osaka Institute of Public Health) / Atsushi Yamamoto (Tottori University of Environmental Studies)

■Invited

Takeshi Hasegawa (Kyoto University)

■Scope

Per- and polyfluoroalkyl substances (PFAS) are compounds with highly fluorine substituted alkyl groups in their structural formula. PFAS have unique properties and are used in a variety of products such as water and oil repellents, antifouling agents, foam extinguishing agents and cosmetics, and we are benefiting from this property. On the other hand, the accumulation of PFAS in living organisms and the environment and their ecological effects have become a worldwide problem. In this session, we would like to have a lecture on the latest results of PFAS research in Japan, and would like to have a discussion on what is known now, what should be done in the future, and the use of mass spectrometers for PFAS research.

■Keywords

PFAS, environment, materials, human, LC-MS/MS

■Session No.

3C-S

■Title

Future of Mass Spectrometry Caused by Development of Ion Mobility and Other Instrumentation

■Organizer

Takae Takeuchi (Osaka University) / Fuminori Misaizu (Tohoku University)

■Keynote

Daiki Asakawa (National Institute of Advanced Industrial Science and Technology)

■Scope

Not only mere mass-to-charge data but also some additional information can now be obtained from mass spectrometric methods by combination with other techniques such as ion mobility spectrometry, fragmentations, and so on. In particular, ion mobility spectrometry is utilized to analyze structures and to separate spatially the isomers of ions of clusters, complexes, biomolecules, etc. These analytical techniques are now combined with commercial mass spectrometers. However, there have been a history of development of instrumentation in Japan by researchers in atomic and molecular physics or in physical chemistry. In this session, we are aiming to discuss the present and future on the instrumentation and its applications of these techniques and others such as ionization and excitation methods from the broad presentations on fundamental and applied research.

■Keywords

ion mobility, instrumentation, hardware core technology, ionization, excitation

■Session No.

2A-O

■Title

Asia and Oceania International Session - New Wind Blowing in Asia -

■Organizer

Masahiro Miyashita (Kyoto University) / Kanako Sekimoto (Yokohama City University)

■Invited

Low Teck Yew (Universiti Kebangsaan Malaysia)

■Scope

Research activity on mass spectrometry from the Asia-Oceania region has been expanding more and more. The AOMSC, which was launched in Tsukuba in 2010, has been expanding every two year, and will be held in Japan again in 2025. In this session, as in the previous year, we would like to share with you the new winds blowing in Asia by freely discussing the latest research results with young researchers who are active in the Asia-Oceania region.

Basic Sessions

■Day 1 Monday, May 15 [Program]
■Day 2 Tuesday, May 16 [Program]
■Day 3 Wednesday, May 17 [Program]

Oral presentations in the Basic Sessions will be selected according to area of research.

Session Overview

■Session No.

1A-O

■Title

Omics

■Chairperson

Yoshihuro Izumi (Kyushu University) / Naoyuki Sugiyama (Kyoto University)

■Session No.

1B-O

■Title

Isotope and Accelerator

■Chairperson

Hirochika Sumino (University of Tokyo) / Kohei Fukuda (Osaka University)

■Session No.

2B-O

■Title

Instrumentation, Informatics, Fundamental Technology, Ionization

■Chairperson

Satoshi Ninomiya (University of Yamanashi) / Tohru Yamagaki (Suntory Foundation for Life Sciences)

■Session No.

3A-O

■Title

Structural Analysis of Anything

■Chairperson

Hideya Kawasaki (Kansai University) / Yoichi Otsuka (Osaka University)

■Session No.

3B-O

■Title

Quantitative Analysis of Anything

■Chairperson

Akira Oikawa (Kyoto University) / Katsuyoshi Masuda (Kyoto University)

Young Researchers' Sessions

■Day 1 Monday, May 15 [Program]
■Day 2 Tuesday, May 16 [Program]
■Day 3 Wednesday, May 17 [Program]

The Young Researchers' Sessions will be designed to be a cross-disciplinary session with selected oral presentations by students and young researchers.

Session Overview

■Session No.

1C-O

■Title

Young Researchers’ Session 1

■Chairperson

Keijiro Ohshimo (Tohoku University) / Lee Chuin Chen (University of Yamanashi)

■Session No.

2C-O

■Title

Young Researchers’ Session 2

■Chairperson

Katsuyoshi Masuda (Kyoto University) / Akira Oikawa (Kyoto University)

■Session No.

3C-O

■Title

Young Researchers’ Session 3

■Chairperson

Kosuke Ogata (Kyoto University) / Kohta Nakatani (Kyusyu University)

Poster Presentations

■Day 1 Monday, May 15 [Program]
■Day 2 Tuesday, May 16 [Program]
■Day 3 Wednesday, May 17 [Program]

Special Evening Sessions

[Program]

Session Overview

■Session No.

1A-E

■Title

Mass Spectrometry Anywhere

■Organizer

Munehiro Katagi (Osaka Medical and Pharmaceutical University)

■Session No.

1B-E

■Title

Panel Discussion ~ Let’s Talk About Case Studies of Matrix Effects That Affect LC-MS Quantitative Analysis and How to Avoid Them! ~

■Organizer

Masayuki Kubota (Nihon Waters K.K.)