The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-47　　PDF

Hybrid Imaging of Biological Tissues: Toward the Atlas of Molecules, Elements, and Metals in Brain Diseases

(1Dokkyo Med. Univ., 2Univ. Tokyo, 3Tokyo Univ. Phar., 4QST)
oTadayuki Ogawa1, Eisei Tanaka2, Tomonari Umemura3, Shino Takeda4, Takafumi Hirata2

In our body, various molecules constitute tissues and organs, and work efficiently to fulfill their physiological function in a coordinated and dynamic manner. When the molecular coordination breaks down for some reason, its pathological modulation appears as disease. Therefore, it is important to obtain as much information as possible on the quality and localization of all molecules and atoms on the body tissue and to analyze them precisely in an integrated manner. In this talk, we will present about the integrated analyses of the same tissue from a human brain by applying various analytical methods, combining the conventional histological analyses with MALDI (matrix-assisted laser desorption/ionization)-IMS (imaging mass spectrometry), SALDI (surface-assisted laser desorption/ionization)-IMS, LA (laser ablation)-ICP-MS, and PIXE (particle induced X-ray emission). We will discuss the current situation and issues, and introduce our efforts on integrated omics analyses against human disease brains in order to elucidate the disease mechanisms. Our studies show mass spectrometry is a promising approach that can deepen our knowledge about the localization of biological molecules in human brain tissue during pathogenesis.