The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-46　　PDF

Feasibility study for the MALDI mass spectrometry imaging of boron neutron capture therapy drug, L-4- phenylalanineboronic acid (BPA) in a brain tumor model rat

(1Osaka Univ., 2Osaka Univ., 3OUJRAL)
oYumi Miyake1, Sachie Kusaka2, Yugo Tokumaru2, Isao Murata2, Michisato Toyoda1,3

Boron neutron capture therapy (BNCT) is a cell-selective particle therapy for cancer using boron containing drugs. Boron compounds are accumulated in high concentration of tens ppm level of boron in target tumors to cause lethal damage to tumor tissue. We examined matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) to visualize the distribution of a typical BNCT drug, L-4-phenylalanine boronic acid (BPA) in a brain tumor model rat using a spiral orbit-type time of flight (SpiralTOF) mass spectrometer.