The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-33（1C-O-1115）　　PDF

Development of Mass Spectrometry Imaging Using Laser Ablation Electrospray Ionization Separated by Gas Transportation with Heating Tube

(1Osaka Univ., 2Osaka Univ.)
oRiku Hirotani1, Hisanao Hazama1, Kunio Awazu2

Intracellular molecular imaging is an important method for the analysis of pharmacokinetics. Mass spectrometry imaging (MSI) will be useful for development of new drugs because it enables simultaneous detection of components. Laser ablation electrospray ionization with gas transportation (LAESI-GT) was developed to achieve MSI with a pixel size of 1 µm or less at atmospheric pressure without application of matrix and voltage to sample. LAESI is a combination of laser ablation and electrospray ionization. Imaging of small molecule samples, caffeine showed their distributions at a pixel size of 40 µm for the first time. The LAESI-GT is expected to be applied to high throughput imaging under atmospheric pressure but further improvement in the detection sensitivity is required.