The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-30　　PDF

Investigation of proton transfer reaction model in condensed phase in MALDI method

(1Niigata Univ. Pharm. Appl. Sci. Graduate School of Pharmaceutical science, 2Niigata Univ. Pharm. Appl. Sci., 3Hokkaido Univ., 4Niigata Univ Med & Dent Hosp, Department of Pharmacy)
oMasafumi Kobayashi1,4, Tatsuro Shirota2, Masashi Tsuge3, Kennosuke Hoshina2

In order to quantitatively evaluate the MALDI ion signal, we examined the reproducibility of the experimental values using quantum chemical calculations under the condition that the proton transfer reaction occurs in the condensed phase of matrix molecules.　As a result, the reproducibility of the MALDI signal ratio was significantly improved compared to a previous model that assumed a gas-phase reaction. This model approach was shown to be a promising method for quantitative treatment of the MALDI signal.