The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 3, May 17（Wed.）　　Room P (Foyer, Room 1004-1007)

3P-29（1C-O-1045）　　PDF

3D Imaging of Metabolic Effects of the Brains from Murine Models of Glioma Treated with Boron Neutron Capture Therapy (BNCT)

(1Doshisha Univ., 2Kyoto Univ., 3Shimadzu)
oNao Kobayashi1, Natsuko Kondo2, Yoshinori Sakurai2, Minoru Suzuki2, Shinichi Yamaguchi3, Masaya Ikegawa1

Here we apply an untargeted mass spectrometry-based metabolomics approach by imaging mass spectrometry in combination with UMAP method. This protocol enabled to visualize differences in broad array of metabolites in anatomical regions of the whole brain of brain tumor transplanted mice before and after boron neutron capture therapy (BNCT). This study yields important platform for metabolomics phenotyping of whole brain of brain tumor transplanted mice by defining regional homeostasis for the brain tumors to give context to the reaction to BNCT. Three-dimensional whole brain imaging will expand the possibilities for understanding the state of the brain.