The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Young Researchers' Sessions

Day 3, May 17（Wed.）　10:30-10:45　Room C (Room 1009)

3C-O-1030（1P-05）　　PDF

Clinical N-glycoproteomics for the exploration of diagnostic markers for Pancreatic cancer

(1Yokohama City Univ., 2Yokohama City Univ.)
oTakeshi Mukai1, Daisuke Takakura1, Shoko Ohashi1, Motohiko Tokuhisa2, Noritoshi Kobayashi2, Yasushi Ichikawa2, Nana Kawasaki1

Label-free quantitative N-glycoproteomics was performed using serum from patients with advanced pancreatic cancer (PC) and healthy individuals. A total of 6,714 N-glycoforms derived from 501 proteins were identified in patients with advanced PC and healthy individual. We found that mono- or di-sialyl biantennary glycan-modified fibrinogen gamma chain (FGG) was increased in serum from advanced PC group. FGG is expected to be used as a diagnostic marker for PC (Area Under the ROC Curve = 1.0).