The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Lunchtime Seminars

Day 3, May 17（Wed.）　12:00-13:00　Room B (Room 1202)

3B-L-1200　　PDF

Introduction of Latest Applications Using Tandem Quadrupole Mass Spectrometer Xevo TQ Absolute coupled with MaxPeak Technology -Improvement of Chromatography and MS Sensitivity-

(Nihon Waters)
oMotoji Oshikata, Etsuko Yada, Maki Terasaki

Liquid chromatograph-mass spectrometers (LC-MS/MS) are used for variety of application as a highly selective and sensitive quantification technology. In some cases, the reproducibility, sensitivity, and robustness of the measurement systems (sample preparation, LC separation and MS detection) are affected by the physicochemical properties of the analyte and/or matrices, and it takes a longer time to develop a LC-MS/MS method. In particular, phosphoric acid, carboxylic acid, or amino functional groups will interact with metal surface of analytical systems, then cause poor peak shape and resulting in decreased sensitivity, reproducibility, and robustness. This work will discuss solution for challenging LC-MS/MS method development for perfluoroalkyl substances (PFAS) in drinking water and oligonucleotides bioanalysis as examples.