The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Basic Sessions

Day 3, May 17（Wed.）　09:33-09:51　Room A (Special Conference Room)

3A-O-0933　　PDF

Development of Chiral Stationary Phase for Chromatography Using Mass Spectrometric Screening

(1ORIST, 2Osaka Inst. Tech., 3Osaka Univ.)
oMotohiro Shizuma1,2, Shota Lee2, Tsuyoshi Matsuzaki3, Kaori Asano3, Shintaro Kawano1, Hirofumi Sato1, Masahiro Muraoka2, Takeyuki Suzuki3

As inulin which is one of polysaccharides has polyoxyethylene structure as the main chain, it makes noncovalent complex with cationic species via charge-dipole electrostatic intermolecular interaction. The chiral discrimination ability of the oligomer mixture of inulin derivative (methyl, benzyl, acetyl, and benzoyl) toward several 2-propyl ester of protonated chiral amino acid was evaluated using fast atom bombardment mass spectrometry coupled with the isotopically labeled guest method which was proposed by Sawada et al. Permethylated inulin among the inulin derivatives showed high chiral discrimination ability toward given chiral cations. Permethylated inulin was fixed on silica gel to use as chiral stationary phase in liquid chromatography and the chiral separation factor toward chiral ammonium ion was examined. The separation factors values showed linear relationship to the chiral discrimination ability in the FABMS screening.