The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 2, May 16（Tue.）　　Room P (Foyer, Room 1004-1007)

2P-55　　PDF

Effect of Probe Oscillation Frequency on Mass Spectrometry Imaging of Mouse Brain Sections by t-SPESI

(1Osaka Univ., 2Osaka Univ.)
oMengze Sun1, Yoichi Otsuka1, Maki Okada1, Shuichi Shimma2, Michisato Toyoda1

Mass spectrometry imaging (MSI) is a powerful method for investigating the distribution of various components in tissue samples. Our group developed a tapping mode scanning probe electrospray ionization method to perform MSI. In t-SPESI, an oscillating probe is scanned over the sample, with charged solvent flow through, at the tip, forming a liquid bridge, and picoliters of solvent absorb and ionize sample molecules and deliver them to the mass spectrometer. . In order to improve imaging quality, it is necessary to understand the vibration of the probe. Therefore, we conducted an experiment to investigate the effect of vibration frequency on MSI, and the relationship between the distance between the tip and the sample and the vibration conditions. The results revealed an attractive interaction that exists between probe and sample in positive mode.