The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Symposium Sessions

Day 2, May 16（Tue.）　09:55-10:15　Room A (Special Conference Room)

2A-O-0955　　PDF

Development of QTOF mass spectrometer equipped with Oxygen Attachment Dissociation (OAD)-MS/MS

(Shimadzu Co.)
oHidenori Takahashi, Yohei Arao

Radical-induced dissociation techniques are widely used for organic structure analysis, providing complementary information to low-energy collision-induced dissociation. However, existing methods like electron capture dissociation and electron transfer dissociation have limitations in analyzing small-molecule compounds that primarily produce singly charged ions. We have developed a novel radical-induced dissociation method that can be applied to singly charged ions and both positive/negative ion modes using atomic/molecular-ion reactions with radical sources such as atomic hydrogen, atomic oxygen, and hydroxyl radicals. A QTOF mass spectrometer equipped with oxygen attachment dissociation (OAD-MS/MS) was demonstrated in lipid analysis. This approach enabled the identification of the positions of carbon-carbon double bonds, which are crucial in determining lipid functions. In the presentation, we will also report on the applications of OAD-MS/MS beyond lipid analysis, such as the analysis of alkaloid compounds in foods and natural product.