The Mass Spectrometry society of Japan - The 71st Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lecture

Symposium Sessions (Day1, Day2, Day3)

Basic Sessions (Day1, Day2, Day3)

Young Researchers' Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Special Evening Sessions

Corporate Program

Poster Presentations

Day 1, May 15（Mon.）　　Room P (Foyer, Room 1004-1007)

1P-12　　PDF

Distribution analysis of galanthamine, a plant alkaloid, by MS imaging

(1Shimadzu, 2Osaka Univ.)
oKaoru Nakagawa1, Tetsuo Iida1, Shuichi Shimma2, Manami Kobayashi1

Plant alkaloids are used in various pharmaceuticals, such as anticancer drugs and analgesics. Among these plant alkaloids, galanthamine is an Amaryllidaceae-type alkaloid with acetylcholinesterase inhibitor for the treatment of neurological diseases such as Alzheimer's disease. Although the chemical synthesis of galanthamine has been successfully achieved, Narcissus is the main source of its production. Research indicates that galanthamine content varies not only with the type of Narcissus, but also with the developmental stage and the part of the plant. Pharmaceutical companies are pursuing plant species with higher galanthamine content to increase pharmaceutical productivity. Therefore, we quickly confirmed the Narcissus in our study contained galanthamine using DPiMSTM QT which is a kit for direct probe ionization unit and a quadrupole time-of-flight mass spectrometer (Q-TOF). Subsequently, we analyzed the distribution of galanthamine by MS imaging (MSI) using the iMScopeTM QT combined with Q-TOF.