演題概要

ポスター発表

第3日　5月13日（水）　　P会場（1008/09）

3P-38　　PDF

MALDI-Imaging Mass Spectrometryを用いた嗅覚障害・再生モデルの解析

(¹同志社大生命医・ ²ブルカージャパン)
^o韮澤崇²・ 亀山大樹¹・ 友野卓也¹・ 外山友美子¹・ 梶田遼²・ 角田伸人¹・ 池川雅哉¹

The olfactory bulb (OB) is the first relay on the olfactory sensory pathway and the target of the neural progenitor cells generated in the subventricular zone (SVZ) lining the lateral ventricles and which migrate along the rostral extension of the SVZ, also called the rostral migratory stream (RMS). Here we generate murine olfactory deprivation model by surgical unilateral nostril closure with a single intraperitoneal administration of Methimazole (MT), a drug for hyperthyroidism with a unique side effect of temporary and reversible olfactory epithelium (OE) depletion. On this model, we have defined proteomic basis of OB-RMS-SVZ axis using high speed MALDI imaging mass spectrometry.