演題概要

ポスター発表

第2日　5月12日（火）　　P会場（1008/09）

2P-21　　PDF

ESI-CIDにおけるカチノン類の代謝物の脱水イオン生成機構の解明

(¹大阪府警科捜研・ ²金沢大院自然)
^o松田駿太朗^1,2・ 志摩典明¹・ 掛橋秀直¹・ 鎌田寛恵¹・ 西山嘉男²・ 永谷広久²・ 井村久則²・ 片木宗弘¹

We examined the generation mechanism of dehydrated ions for metabolites of cathinones during ESI-CID through the stable-isotope labeling experiments. It is shown that the two major tertiary amine metabolites (1-OH and 2"-oxo) of cathinones generated dehydrated ions in ESI-CID. The dehydration of the 1-OH metabolite following a simple mechanism where the hydroxy group was eliminated together with the proton added during ESI. In contrast, the dehydration mechanism of the 2"-oxo metabolite involved hydrogen atoms in three or more locations along with the carbonyl group oxygen, indicating that dehydration occurred via multiple mechanisms. These findings presented herein indicate that the dehydrated ions in ESI-CID will be useful for the structural identification of cathinones.