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第1日　5月11日（月）　17:15～17:30　C会場（1101/02）

1C-O3-1715（1P-42）　　PDF

Mass Spectrometry Based Investigation of Photobleaching Coefficient of Protoporphyrin IX Used in Photodynamic Diagnosis and Therapy of Cancer

(¹Grad. School of Eng., Osaka Univ.・ ²Grad. School of Front. Biosci., Osaka Univ.・ ³MEI Center, Osaka Univ.)
^oSochi, Ogbonna¹・ Hazama, Hisanao¹・ Awazu, Kunio^1,2,3

Photobleaching is one of the phenomena that hinders the effectiveness of photodynamic diagnosis and therapy (PDD/PDT); a cancer diagnosis and treatment technique. We used electrospray ionization mass spectrometry to investigate the photobleaching coefficient β during PDD/PDT. Fluorescence-based investigation of the photobleaching under the same conditions was carried out, and the obtained results were compared with the mass spectrometry-based β value. Variations in the β values from the two investigations were observed, although both β values were within the literature range.