オーラルセッション
- 第1日 5月11日（月） 17:00～17:15 C会場（1101/02）
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1C-O3-1700（1P-41） PDF
時系列メタボローム解析を用いたがん細胞薬剤応答の解明
A metabolic response of the human breast cancer cell line (MCF-7) against a treatment of 4-hydroxytamoxfen (4-OHT) was investigated by the metabolic profiling analysis using GC-MS, LC-MS/MS and LC-q-ToF-MS. The results showed that the levels citrate and succinate decreased, fumarate and malate increased at 12 h, respectively, suggesting an inhibition of complex Ⅰ after the 4-OHT treatment.