演題概要

ポスター発表

第3日　5月17日（金）　　P会場（多目的ホール）

3P-15　　PDF

イメージング質量分析を用いたマウス全身切片中の薬物分布

(¹旭化成ファーマ・ ²旭化成)
^o小松里香^1,2・ 山本豊彦²・ 坂部輝御²・ 小川潔¹

Imaging mass spectrometry (IMS) can reveal the distribution of drugs and their metabolites on tissue sections. Therefore, it is useful for elucidation of mechanisms of pharmacokinetics, efficacy and toxicity. Although, the IMS technology has evolved remarkably, there are many problems to use of drug discovery research. Particularly, it is difficult to apply to whole-body tissue sections and acquire distribution of compounds that are low sensitivity in tissues. In this study, we attempted acquisition of celecoxib distribution in mouse whole-body tissue sections.