目次
オーラルセッション
- 第3日 5月17日（金） 14:45～15:05 B会場（102）
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3B-O2-1445 PDF
創薬研究への定量的イメージング質量分析の活用
Imaging mass spectrometry (IMS) enables to visualize the distribution of various molecules without labeling by ionizing a lot of molecules on tissue sections using a mass spectrometer. We previously reported the quantitative analysis approach for tissue distribution of drugs by matrix-assisted laser desorption/ionization (MALDI)-IMS. In this symposium, I would like to introduce the case studies for application of quantitative imaging mass spectrometry to a mechanism understanding for efficacy of candidate compounds and pharmacokinetic/pharmacodynamic (PK/PD) analysis in drug discovery and development.