目次
ポスター発表
- 第2日 5月16日（木） P会場（多目的ホール）
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2P-22 PDF
核酸医薬品不純物のLC/TOF-MS分析
Oligonucleotides are chemically synthesized compounds and have recently attracted attention as a “new modality”. Due to the large molecular weight of oligonucleotides, TOF/MS is used for the analysis because of its wide mass range, but analysis of impurities is considered as a bottleneck for automation. We show that several split impurities are detected in degradated sample of 21mer using by LC/TOF-MS and Oligosearch software.