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1P-39 PDF
代謝プロファイル時系列分によるがん薬剤耐性化機構の解明
A metabolic response of the human breast cancer cell line (MCF-7) against a υtreatment of paclitaxcel, an antimitotic agent, was investigated by the metabolic profiling analysis using GC-MS. The results showed that the levels pyruvate and phosphoenolpyruvate decreased and increased at 3 h, respectively, suggesting an inhibition of pyruvate kinase after the paclitaxcel treatment.