Program

Poster Presentations

Day 3, May 17（Thu.）　　Poster

3P-46　　PDF

High resolution trapped ion mobility mass spectrometry analysis of isomeric compounds

(¹Bruker Japan, ²Bruker Daltonics)
^oYoshifumi Mori¹, Sven Meyer², Peter Sander², Annette Michalski², Detlev Suckau²

Ion mobility (IM) separation hyphenated with high resolution accurate MS extends substance identification and characterization capabilities to a new dimension. IM permits to separate isobaric or isomeric compounds.　We applied Trapped Ion Mobility Separation (TIMS) on the new timsTOFTM instrument(Fig.1). Model compounds were isomeric trisaccharides or lipids. In real-world samples these compounds are difficult to identify using LC-MS-only methods as these don´t provide clean MS/MS spectra. Using the timsTOF with its ion mobility expansion technology (imeXTM) facilitated method development for an appropriate IMS separation.