Program

Poster Presentations

Day 3, May 17（Thu.）　　Poster

3P-15　　PDF

In Situ proteomics of Kidney from Type 2 Diabetes Mellitus (T2DM) Rat using MALDI-Imaging Mass Spectrometry

(¹Doshisha Univ., ²Bruker Japan K.K.)
^oYuki Kuzuhara¹, Yume Mukasa¹, Takashi Nirasawa², Nobuto Kakuda¹, Masaya Ikegawa¹

The development of an experimental animal model with diabetic nephropathy that closely mirrors human disease will significantly enhance our understanding of the nephropathy and accelerate our progress toward more effective treatments.In this investigation, we adopt ultra-high speed matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis in an integrated workflow to study proteomic alteration of diabetic nephropathy reproduced on kidneys from model rats.