Program

Poster Presentations

Day 3, June 12（Fri.）　　Room P (5F 501+502)

3P-47

PDF

Elucidating Fetal Metabolic Remodeling Dependent on Maternal Gut Microbiota and Developmental Stage

(¹Tokyo Univ. Agr. Tech., ²Tokyo Univ. Agr. Tech., ³Tokyo Univ. Agr. Tech., ⁴Tokyo Univ. Agr. Tech., ⁵Kyoto Univ.)
^oKoki Nagatomo¹, Junki Miyamoto², Ayana Okamoto³, Hiroshi Tsugawa^4,5

Maternal gut microbiota is suggested to influence fetal development and postnatal metabolism,　but how it modulates maternal–fetal metabolic coupling remains unclear. We compared lipid remodeling in fetal liver and placenta from germ-free (GF) and specific pathogen-free (SPF) pregnant mice at embryonic day 12, 15, and 18, and fetal liver at postnatal day 0. Non-targeted lipidomics followed by multivariate data mining revealed microbiota-dependent lipid signatures. In placenta, SPF samples showed higher levels of polyunsaturated fatty acid (PUFA) containing triacylglycerols, whereas GF fetal livers exhibited increased diacylglycerols and free fatty acids. Notably, SPF fetal livers displayed elevated acylcarnitine with decreased free PUFAs specifically at the specific time point, suggesting that late-gestation maturation of fetal fatty-acid metabolism is associated with maternal microbiota status.

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