Sweets Seminar
Day 2, June 11（Thu.） 14:30-15:00 Room B (4F 411+412)
- 2B-SW-1430
Evolution of ZT Scan DIA on Q-TOF system and the latest SCIEX solution
(AB SCIEX)
oYuki Shimozu
Previously, ZT Scan DIA (Data-Independent Acquisition) was introduced as an alternative approach by employing a scanning quadrupole for precursor isolation in combination with the Zeno trap. The next iteration introduced here reduces the isolation window width from 5 Da to a minimum of 1 Da, while enabling faster accumulation times. This significantly decreases co-isolation, enhancing precise precursor-fragment mapping and improving confidence in peptide identifications. We introduce how Q1 isolation width affects identification depth across a range of gradients and LC regimes. Additionally, we will introduce the latest SCIEX solutions shown at ASMS.