Poster Presentations
Day 1, June 10（Wed.） Room P (5F 501+502)
- 1P-28
Development of Mass Spectrometry Imaging Method Using Atmospheric Pressure Infra-Red Matrix Assisted Laser Desorption Ionization
(UOsaka)
oRensei Tsumura, Hisanao Hazama, Kouki Ueno
Intracellular molecular imaging is an important method for the analysis of medicine dynamics. In particular, mass spectrometry imaging will develop new drugs because it enables simultaneous detection of components, and qualitative and quantitative analysis. This study developed an imaging technique using atmospheric pressure infra-red laser desorption ionization (AP-IR-LDI), which can overcome the limitations of conventional ionization methods. Measurements of aqueous samples were performed using this ionization method while varying the fluence and wavelength, resulting in the determination of optimal fluence and wavelength conditions. However, two-dimensional imaging of biological tissue revealed various challenges. Solutions to these challenges are required for the development of an ionization method with higher precision and reproducibility.